Clinical Research at SightMD
One of the most exciting aspects of medicine is continuous innovation, scientific exploration, and research into how we can provide enhanced care for our patients. The field of ophthalmology has been on the forefront and recipient of revolutionizing technology, novel medications, premium devices, and innovative surgical techniques. Individually or combined, these advancements have provided patients with better vision and improved treatment options.
At SightMD we are continuously coupling efforts with top-tiered patient-centric industry-leading companies to bring the newest techniques, technologies, and medications to our patients through our Department of Clinical Research. Lead by Dr. Alanna Nattis, she has designed, developed, and exclusively accessed investigational treatment studies for wide-ranging ophthalmic conditions such as severe dry eye, glaucoma, refractive and cataract surgery, and retinal pathologies. Having direct access to FDA clinical trials uniquely provides SightMD with state-of-the-art care for our current and future patients.
Ongoing/Currently Enrolling Research Studies
We are currently recruiting for several active clinical trials. Please contact us for more information!
A non-interventional, observational study to evaluate treatment patterns and safety of avacincaptad pegol (ACP/IZERVAY) in routine clinical practice in patients with geographic atrophy secondary to age related macular degeneration
Non-interventional (observational) study evaluating treatment efficacy of IZERVAY in patients with geographic atrophy
- PI: Edward Marcus, MD
- Research Coordinator: Maria Alvarez
- Stage of Recruitment: open
- Trial type: Phase 3 FDA
An observational real-world evidence study of ab-interno goniotomy performed using the C-REX instrument in patients with primary open angle glaucoma (The Circle Registry)
Evaluation of ab-interno goniotomy device on POAG outcomes in a real-world setting
- PI: Raju Sarwal, MD
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- Research Coordinator: Maria Alvarez
- Stage of Recruitment: Open
- Trial type: observational, prospective
Eye exams provided to patients undergoing investigational research for novel chemotherapeutics/therapeutic regimens across the greater NYC area and Long Island
PI: several physicians across SightMD locations
Stage of Recruitment: Open
Designed to gather data to further understand genetic risk factors associated with AMD
- PI: Edward Marcus, MD (SMD NY, NJ, PA, CT locations to enroll as well)
- Research Coordinator: Maria Alvarez
- Stage of Recruitment: Open
- Trial Type: Pilot/Epidemiological
Evaluation of patient and provider perceptions and knowledge regarding diagnosis and treatment of demodex blepharitis in a real-world setting
- PI: Alanna Nattis, DO
- Sub-I: Eric Rosenberg, DO
- Research Coordinator: Kathy Lemier
- Stage of Recruitment: Closed for data collection
- Trial type: Observational post-market
A Real World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses
Evaluation in a long-term follow up time frame of the AcrySof single-piece and AcrySof multi-piece monofocal intraocular lenses
- PI: Alanna Nattis, DO
- Sub-I: Eric Rosenberg, DO
- Research Coordinator: Kathy Lemier
- Stage of Recruitment: Open
- Trial Type: Phase 4 post-market
Long-term evaluation of safety and performance of Clareon Presbyopia Correcting IOLs – PMCF Study of Clareon Vivity & Clareon PanOptix
Long-term evaluation of patients post-bilateral implantation of Clareon Panoptix and/or Vivity intraocular lenses
- PI: Alanna Nattis, DO
- Sub-I: Eric Rosenberg, DO
- Research Coordinator: Kathy Lemier
- Stage of Recruitment: Open
- Trial type: Phase 4, post-market
Randomized, Placebo-Controlled, Double-Masked Study of the Safety and Efficacy of POS (0.75% Phentolamine Ophthalmic Solution) in Subjects Who Have Previously Had Keratorefractive Surgery and Have Decreased Visual Acuity Under Mesopic Conditions
Evaluation of miotic eye drop on improvement in visual acuity and visual disturbances in patients who are post-LASIK/refractive surgery
- PI: Jeffrey Martin, MD
- Research Coordinator: Kelly Killoran
- Stage of Recruitment: Open
- Trial Type: Phase 3
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety and Tolerability of Subcutaneously Administered Pozelimab in Combination with Cemdisiran or Cemdisiran Alone in Patients with Geographic Atrophy Secondary to Age Related Macular Degeneration
Evaluation of subcutaneous medication on geographic atrophy in dry AMD
- PI: Ed Marcus MD
- Sub-I: Norman Saffra MD, Sabah Shah MD
- Research Coordinator: Maria Alvarez
- Stage of Recruitment: Open
- Trial type: Phase 3
Intraocular Pressure, Pachymetry & Keratometry Assessment Utilizing a Novel Non-invasive Device vs. Standard-of-Care Diagnostics
Comparison of a 4:1 novel device (TRK-3) on measuring IOP, pachymetry, keratometry and autorefraction compared to standard of care devices
- PI: Alanna Nattis, DO
- Sub-I: Eric Rosenberg, DO, Richard Nattis MD
- Research Coordinator: Kathy Lemier
- Sub-coordinator: Nathaly Vasquez
- Stage of Recruitment: Open
Soon-to-be-Enrolling Studies
We will be looking open up the following clinical trials soon. Please contact us for more information!
A phase 3, randomized, multi-center, placebo-controlled, masked study to evaluate the clinical efficacy and safety of Fucithalmic (Fusidic Acid 1%) viscous topical antibiotic eye drops for the treatment of suspected bacterial conjunctivitis
Evaluation of a broad spectrum antibiotic with extensive use outside of the US on bacterial conjunctivitis cases
- PI: Alanna Nattis, DO
- Sub-I: Eric Rosenberg, DO
- Research Coordinator: Kathy Lemier
- Sub-coordinator: Mary Iaconis
A phase 3, randomized, active-controlled double-masked study to evaluate the safety and efficacy of TRS01 eye drops in the treatment of subjects with active non-infectious anterior uveitis including subjects with uveitic glaucoma
Evaluation of a novel eye drop for treatment of non-infectious anterior uveitis and subset of patients with uveitic glaucoma
- PI: Norman Saffra, MD
- Research Coordinator: Maria Alvarez
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